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It's the equivalent of taking an anti-depressant for the first six months, but with a 30 percent lower relapse rate over the next two years.
The significantly lower relapse rate of frovatriptan can be explained by its pharmacological properties [21].
Findings: Methadone detoxification results in higher retention in treatment, lower relapse rate and fewer side effects when compared with adrenergic agonists.
Our data show that frovatriptan results in a significantly lower relapse rate even when taken in acute migraine attacks with aura as compared rizatriptan, zolmitriptan, and almotriptan (the latter one not at 48 hours).
In OPERA I, ocrelizumab-treated patients had a 46% lower relapse rate with 0.16 vs. 0.29 (p < 0.001), and similarly in OPERA II, there was a 47% lower rate with 0.16 vs. 0.29 (p < 0.001).
However, in the study by Bøe et al. [25], a much lower relapse rate at 12 months follow-up was found among individuals with ≥50% improvement score at 3 months follow-up than among those without such improvement (4 vs. 28%).
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The research showed that patients outside the United States and Europe had significantly lower relapse rates — as much as two-thirds lower in one follow-up study.
Frovatriptan resulted in significantly lower relapse rates at 24 hours and 48 hours when taken in migraine attacks with aura.
Additionally, the overuse of triptans leads to MOH faster and with lower dosages compared to ergots or analgesics, while it is also characterized by shorter and easier withdrawal with lower relapse rates compared to analgesics overuse [2].
Research is finding that young adults often respond with better survival rates and lower relapse rates when they are treated using pediatric protocols.
The US National Institute on Drug Abuse (NIDA) recommends a minimum of 90 days (or longer) for most treatment programs due to the lower relapse rates associated with longer treatment programs.
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