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These patients experienced a significantly lower rate of response, with respect to patients harbouring the other genotypes.
In contrast, previous data on PMR [ 12] and rheumatoid arthritis [ 13] have reported higher disease severity and lower rate of response to GC in women.
Since then, several studies [ 37- 39] have demonstrated that elevated pretreatment serum HER-2/neu levels are associated with a significantly lower rate of response to endocrine therapy.
Our study also showed a lower rate of response to trastuzumab and shorter PFS for PTEN non-expressors (PFS of 12.1 versus 15.3 months).
P was calculated with Pearson-χ2 two-sided test with continuity correction Patients harbouring both the CYP1B1 4326GG and 412GG genotype (N = 9) also experienced a significant lower rate of response (P = 0.039), with respect to patients (N = 51) harbouring the other genotypes.
There appeared to be an association between elastosis and response: tumours with no elastosis showed a lower rate of response than those with gross elastosis, indicating that this simple method might provide a useful predictive index for response to endocrine therapy.
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Although the variables from the home questionnaires have lower rates of response, frequencies are nevertheless high at about 90%.
The application of TDM in this survey of Japanese dentists produced lower rates of response than expected from previous Japanese and US studies with little response bias.
The application of TDM in this survey of Japanese dentists produced lower rates of response than expected from previous Japanese and US studies.
The results demonstrate that higher diversity and complexity of quasispecies are related to lower rates of response to peginterferon and ribavirin therapy.
Patients were randomly sampled from each participating practice, with more patients selected in practices likely to have lower rates of response.
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