Sentence examples for lower plaque from inspiring English sources
Reducing Aβ production is predicted to lower plaque burden and mitigate AD symptoms.
Instead, Eppright et al. [15] demonstrated significantly lower plaque index scores in the text message group just at T2, which was four appointments or an average of 5.44 months after baseline (T0).
There was a statistically significant difference between the groups' plaque scores only at the 12-month time point with the gum group and control group having lower plaque scores than the mint group with no statistically significant difference between the gum and control groups (Table 4).
A lower plaque age was also associated with higher levels of plasma insulin and of gene activity related to oxidative phosphorylation and immune responses.
The quantitative analysis of the plaque number revealed that animals treated with 22C4 scFv had a significantly lower plaque number when compared to PBS treated animals (Fig 4 D; * p<0.05).
As expected, the APP695 model group had the highest plaque counts, and the immunized groups had lower plaque counts, albeit not significantly.
Luteolin calms overactive immune cells (microglia), which can damage the brain and helps to lower plaque-forming proteins in the brain.
As a result, the variation in plaque size is generally low in this model which might explain why our treatment lowered plaque numbers but did not significantly affect plaque size.
In an initial experiment, chronic administration of the N-terminal antibody 3D6 (the murine equivalent of bapineuzumab) significantly lowers plaque deposition when treatment was started at 9 months of age (preventative trial), but fails to alter deposition when used in a therapeutic regimen beginning at 18 months of age.
Prior preclinical studies have shown that both active and passive immunotherapies were effective in lowering plaques in transgenic APP mice when performed as a preventative treatment; however, when performed as a therapeutic approach in aged transgenic mice, they lacked any effect on plaque levels [ 15, 50].
This sensitivity, however, is lower in plaque imaging since the plaque size is near the spatial resolution of the system and thus subject to signal loss by partial volume effects.
