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This provides a network based explanation to the observed conservation rates that can also help explain why so many biological processes are well conserved despite the lower levels of conservation for the interactions of proteins participating in these processes.
Based on this scoring system the percent identity was more heavily weighted to ensure that shorter very highly conserved sequences are not ranked below longer sequences with lower levels of conservation (Fig. 1A).
MAP3K1 differs from MAP3K2, MAP3K3 and MAP3K4 in exhibiting lower levels of conservation in its kinase domain and in being a strong stimulator of apoptosis [49].
Dipteran codon families showed slightly more divergence (avg-%INUC = 60.84 ± 8.59), while coleopteran (avg-%INUC = 38.92 ± 8.84) and hymenopteran (avg-%INUC = 37.19 ± 8.22) codon families exhibited much lower levels of conservation.
These peptide-binding sites were expected to have lower levels of conservation because it is well established that the extracellular domains of GPCRs have a large degree of sequence variability.
Because we trained our SVM to discriminate between regions with a fairly large fraction of conserved sites according to phastCons (>25%) and regions with zero conservation according to phastCons, regions with lower levels of conservation may not be properly classified.
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Motif B displays a significantly lower level of conservation among family members, giving rise to a novel α/β structure for the serotonin binding slot.
The distribution of common nsSNPs was biased towards a lower level of conservation, as would be expected for neutral variants with little or no functional significance.
In contrast, some functional groups such as cofactor biosynthesis and amino acid biosynthesis exhibit a lower level of conservation and probably reflect the available nutrients in the niches occupied by the individual streptococcal species.
This binding site showed a lower level of conservation than miR-1279 and miR-548j binding sites.
We were not able to predict a complete P. humanus corporis arginase sequence, because of the lower level of conservation.
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lower degree of conservation
lower levels of resources
lower levels of vitamin
lower levels of confidence
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lower percentages of conservation
lower levels of histamine
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lower frequencies of conservation
lower levels of government
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lower levels of leverage
lower levels of wellbeing
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lower levels of cancer
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