Exact(10)
The remaining 10 orthologs exhibit a significantly lower level of sequence identity (Fig. 5).
The lower level of sequence conservation among ELN orthologs is also associated with differences in gene structure among species.
Compared to the two Plasmodium species, the Theileria species-pair has a lower level of sequence divergence.
No other mutations we made in TMD2 affected substrate cleavage, and given its somewhat lower level of sequence conservation, this domain may simply be required to position the C-terminal domain relative to the rest of Pen-2.
In particular, with respect to the Anopheles homologue, Aeadsx common exons 2 and 4 are largely conserved in size and content, while sex-specifically regulated exons as well as exons 3a and 3b share a lower level of sequence identity.
Comparisons of the human Hoxa cluster to those of marsupials and amphibians reveal a much lower level of sequence conservation over similar periods of time, indicating either a faster rate of molecular evolution in the tetrapod and mammalian lineages or a slower rate of evolution in the cartilaginous fish.
Similar(50)
If so, this lower level of sequencing can be used to compute the depth of sequencing required to adequately sample all of the transcripts.
BLASTN was least efficient compared to BLASTX and TBLASTX, probably owing in part to intron-exon structure in the genome and to lower levels of sequence conservation in untranslated (UTR) regions of transcripts.
Washietl and Hofacker [22] plotted the average z-scores of structural and sequence-based pairwise alignments of SRP RNAs versus pairwise identity and showed that there is a peak in the z-scores for sequence-based alignments around 60% average pairwise sequence identity; z-scores dropped off for both higher and lower levels of sequence identity.
Recent molecular phylogenetic studies [21], [22], [23] revealed a well supported clade with on average twice the level of sequence divergence (the so-called long branch clade, LBC) when compared to a second major clade with lower levels of sequence divergence (the so-called short-branch clade).
When all age groups are compared, group 1 showed significantly (p = 0.04) lower levels of sequence homology compared to the other 3 groups combined (48.5% compared to 52.2%), and the smallest percentage of samples with direct repeats at breakpoints (58.8% compared to 74%) (Table 1).
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