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In agreement, 5-LO deficient (5-LO−/−) mice presented lower lethality rates compared to WT mice.
This fact may be associated with lower lethality of Tityus stigmurus human envenoming when compared to Tityus serrulatus accidents.
The lower ratio for greater lethality level (≥99%) than those of lower lethality, say [97%,98%) for example, is apparent.
Results of pathogenicity experiments indicated that death can occur from the i.c. and i.m. routes of injection, although gt2 viruses showed lower lethality to mice when injected i.m.
By comparison to P. falciparum, the lower lethality of P. vivax may relate to invasion and growth in reticulocytes and lower cytoadhesive properties.
In murine model, RP73 showed lower lethality and a remarkable capability of long-term persistence in chronic airways infection when compared to other strains.
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The lower 18% lethality value observed by Lexicon might be related to examining few genes coding for transcription factors and structural proteins and hybrid vigor from studying C57BL6/J 129SvEv hybrid mice.
We show that in pneumococcal pneumonia, PAR-1 impairs the host defense response, as reflected by a reduced lethality, lower bacterial loads, lower lung histopathology scores and less pulmonary neutrophil influx in PAR-1 KO mice.
As a result, we are cautious about those mutations identified with a recessive lethality lower than 95%.
In the study by Schouten and colleagues, PAR1 impairs the host defence response, as reflected by a reduced lethality, lower bacterial loads, less pulmonary neutrophil influx and less lung damage in PAR1 knockout mice [ 1].
Integrated guidance-autopilot systems are expected to result in significant improvements in missile performance, leading to lower weight and enhanced lethality.
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