Unfortunately a lower response rate (70% predicted, 59% achieved) than anticipated meant that the final sample size was 206, 6% lower than intended (original sample size 220).
"The navigation team realized as the spacecraft approached Mars that it was coming in lower than intended," says head of the investigation board Arthur Stephenson, director of NASA's Marshall Space Flight Center in Huntsville, Alabama.
So the middle deck was thickened to 90 mm with the lower deck intended to catch any splinters penetrating the armor deck.
Even with a small jitter range, if the pursuit were consistently slower than the pursuit target (i.e., pursuit gain <1.0), the actual temporal frequency of the display could be lower than intended.
In fact, compliance with the sensor wear in the control group was lower than intended (around 80%).
Recent years have witnessed a resurgence in the interest in family size intentions and ideals in developed societies, partially stemming from the idea that realized fertility in these societies is lower than intended fertility.
As the authors commented, the size of the study sample is lower than intended, as only 26 pairs were recruited (from the 28-pair calculated sample size) and only seven completed the study, performing an intention-to-treat analysis.
The uncertainty related to the rate of events or the standard deviation in the control group 13 14 and to treatment effect could lead to lower than intended power.
Furthermore, the covariance of both estimates is reduced by 74% compared to Model 2. Recent years have witnessed a renewed scientific interest in family size intentions and ideals in developed societies which seems to stem at least partially from the idea that realized fertility in these societies is lower than intended fertility.
Besides the higher impact of assay variability when using one marker to predict ODTac systemic exposure, the correlation between Ctrough and AUC24 is not optimal as shown in the results and could theoretically lead to therapy failure when exposure is 20%% higher or lower as intended [ 37].
