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Patients with a lower frailty score had a higher overall survival rate (91 % on CC and 83 % to hospital discharge) compared to those with a higher frailty score (70 % on CC and 51%% to hospital discharge).
Participants volunteered for this study, so we may have selected a population with less comorbidity and lower frailty.
Clinics with a high volume tent to have a lower frailty (clinics 7, 31) but this is not true for all of them.
This has obvious health care implications in the light of studies showing that frailty is a dynamic process, characterized by frequent transitions to states of lower frailty and therefore suggesting opportunities not only for preventing but for alleviating frailty [ 27, 41].
The effect of RasGrf1 deletion on aging, which is also accompanied by lower frailty and retention of motor control, appears to be mediated by greater protection against oxidative damage as observed by lower brain lipid peroxidation, liver protein oxidation and maintenance of the brain and liver glutathione redox potential.
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While exercise reduced the risk of death in all participants, it conferred its greatest mortality benefit in those with lower baseline frailty.
The situation for the rural population is different: they have shorter life expectancy and also lower prevalence of frailty, resulting in the lowest frailty burden.
Under this scenario, the NV+AB group would have a 45% lower prevalence of frailty than the control group (adjusted prevalence of frailty 29.6% vs 66.5%, respectively).
Paradoxically smoking was associated with lower risk of frailty in the two Beijing cohorts, while current alcohol use was associated with reduced risk of frailty in all three cohorts (Table 8).
Furthermore, OA seems to be associated with worsening of and/or lower recovery from frailty [ 33].
Concordant with previous studies [ 12, 36], we also observed that current alcohol consumption was associated with lower odds of frailty.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com