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After researchers adjusted for the lower fish consumption of autistic children, they found no differences between their mercury levels and those in other children.
2) One limitation of this study is that the children with autism had more gastrointestinal problems, lower fish consumption, more fish oil consumption, and more probiotic usage.
The data suggest that PBDE levels are somewhat higher in women with higher body mass, who had lower fish consumption, who worked in agriculture, and, paradoxically, among parous women with more months of previous lacation (total PBDEs only).
However, in two studies (Hsu et al. 2007; Marques et al. 2007), differences in intake during pregnancy were not associated with Hg levels in populations whose diet included lower fish consumption, although an association with consumption prior to pregnancy was suggested (Hsu et al. 2007).
Under model 2, which estimates the total effect of diagnostic group on blood Hg (including that mediated through behaviors that alter exposures to Hg), children with AU/ASD were found to have reduced blood Hg concentrations compared with TD controls (β = −0.34, p = 0.02), reflecting their lower fish consumption.
Studies examining the association of fish consumption with various physiological markers indicate that patients with a higher consumption of fish have higher HDL cholesterol [ 17] and albumin levels [ 10], and are less likely to have type 2 diabetes [ 10], compared to patients with lower fish consumption.
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It is attributable to both lower average fish consumption [see Supplemental Material, Table 2 (doi:10.1289/ehp.1002542)] and lower bioaccumulation of DDTs in Tropical fishes (Kannan et al. 1995).
For instance, the overall relative risk of cerebrovascular disease when comparing the highest with the lowest category of fish intake was 0.87 (95% confidence interval 0.82 to 0.92) and for studies with higher and lower average fish consumption was 0.89 (0.78 to 1.01) (P for heterogeneity >0.05; see supplementary fig 11).
This analysis illustrates that the time relative to peak emissions has a significant impact on the reduction in offspring exposure achieved by lowering maternal fish consumption.
This is characterised by the relationship between lower levels of fish consumption and increased incidence of depression.
Indeed, participants having both higher toenail mercury and lower fish or omega-3 consumption tended to have lowest incidence of diabetes, whereas participants having both higher toenail mercury and higher fish or omega-3 consumption did not have a significantly different incidence of diabetes.
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