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The study by Mathai et al [ 8] randomised 101 women and found a marked improvement in the need for analgesia in the first four postoperative hours, a shorter operating time and lower febrile morbidity with the Joel-Cohen technique.
Pigs that were inoculated with recombinant adenovirus for IFN- α expression and challenged one day later with PRRSV had lower febrile responses, reduced lung lesion, and delayed viremia and antibody response compared to controls [ 24].
Nevertheless, basal temperatures are lower in older people and in face of an infectious/inflammatory process, both experimental and human data argue for a lower febrile response in these patients, which may explain our result [ 3, 19- 21].
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It delays the incubation period, lowering down febrile index and PGE context.
Once-per-cycle pegfilgrastim is as effective as daily filgrastim with respect to duration of severe neutropenia (DSN) and may have a lower incidence of febrile neutropenia than filgrastim.
Patients who received leukocyte-reduced blood exhibited a lower incidence of febrile reactions (P = 0.06).
However, upfront dose reduction may result in a lower incidence of febrile neutropenia in these patients.
Besides therapeutic benefits for efficacy, weekly dosed taxanes were reported to be associated with a lower incidence of febrile neutropenia.
Moreover, an online survey of members of the Australian and New Zealand Intensive Care Society Clinical Trials Group found that most respondents reported the use of interventions to lower temperature among febrile patients [ 29].
In primary dengue infection serum IL-10 was slightly lower in the febrile phase (mean 135.8, SD ± 129.7 pg/ml) when compared to the critical phase (mean 154. 2, SD ± 183.2 pg/ml) although not statistically significant.
Unlike the other currently recognized human CoVs, HCoV-229E, HCoV-OC43, HCoV-NL63, and HKU1, which usually cause mild upper respiratory tract infections and occasionally pneumonia in older adults, neonates, and immunocompromised patients (5 – 8 ), SARS-CoV causes severe febrile lower respiratory tract illness that leads to pneumonia and acute respiratory distress (9, 10 ).
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