ALK5 was significantly lower expressed in chondrosarcoma in comparison to cartilage while expression levels of ALK1 were equal.
By applying a 5-fold lower expression threshold in a specific tissue, we identified miRNAs that specifically lower expressed (or avoidant) in a given tissue.
One of the four TFs that showed a constitutive difference between the two genotypes, OsIRO2, was constitutively lower expressed in IR64-Sub1 (Fig. 2a).
The cytotoxicity and internalization efficiency of these nanocarriers have been evaluated on folate receptor over expressed KB and folate receptor lower expressed KG1a cells.
Cyp2b9, a major P450 in the mouse liver was 46.5-fold lower expressed in the SPF compared to GF mice.
Both NAT1 and MYB were found to be lower expressed in the DM group in our data.
The NR farnesoid-X receptor, FXR was also 1.3-fold lower expressed in the SPF compared to GF mice.
Another important gene in circadian regulation, the aryl hydrocarbon receptor nuclear translocator like (arntl or BMAL1) is 7 fold lower expressed in GF mice.
Highly expressed transcripts tended to have more read coverage in AS, whereas SMS tended to cover the lower expressed transcripts more effectively (Table S3).
This is consistent with the higher number of lower expressed miRNAs in ER-negative than in ER-positive tumor samples observed by others [24], [49].
IL1B and IL6 were downregulated, and connected to genes encoding cytokines and antigen presentation molecules that were also lower expressed in HPV-positive cells.
