Sentence examples for lower essentiality from inspiring English sources
Although this rate difference appears to be due to the lower essentiality of extracellular proteins than intracellular proteins in yeast, we here show that, in mammals, the impact of extracellularity is independent from the impact of gene essentiality.
This indicates a strand bias for essentiality, albeit lower than that observed in free-living bacteria.
Finally, while RNAi experiments in worm have reasonably low false-positive and false-negative rates [ 25, 26], we would still expect lower degrees of gene essentiality from this knockdown technique than from gene deletions.
A high number of votes for essentiality led to high specificity, while lower numbers led to higher sensitivity.
The advantage of using such hub proteins as drug targets lies in their essentiality, non-replaceable position in the PIN and lower rate of mutation, which can help to counter bacterial resistance.
Importantly, lower conservation in larger genomes was observed for all classes of operons in terms of gene expression, essentiality, and balanced protein concentration.
However, as some large molecules may not be broken down, we still kept the uptakes for these molecules in two cases: 1) if their uptakes was added during the correction of a false gene essentiality prediction (for example, fatty acids); and 2) if deletions of these uptakes caused a growth rate lower than the defined threshold or generated new false gene essentiality predictions.
Gene essentiality is also an important predictor of gene noise, again consistent with earlier findings that essential genes have lower noise [ 1, 2, 13, 14].
There is a notion of museum essentiality that is by no means beyond debate".
"No one questions the validity, the urgency, the essentiality of the Voting Rights Act," he added.
