Surprisingly, the lower efficacy agonist APO was the more efficacious positive reinforcer.
Degradation or rapid metabolism of a drug candidate usually results in a lower exposure to the efficacious compound leading to a lower efficacy of disease treatment.
Obtained results show that a lower efficacy of single interventions decreased the expected NHB associated with the considered control programs.
An in-furrow application of a granular insecticide has a much lower efficacy than the T-band.
This difference between nicotine and varenicline might be due to the fact that varenicline has a lower efficacy for a variety of nAChRs (Papke et al, 2011).
The compound 3 showed potency similar to benznidazole, but lower efficacy.
"I think nobody will be very interested in a vaccine that is less than 50%." A vaccine with lower efficacy could be a problem if people assume they are protected and take no further precautions against HIV.
The second possibility appears to dominate, which may explain the reported lower efficacy of 5 mC deamination compared with that of C (3-, 10- or 16-fold decrease 6, 27, 37.
Almost 80% of potential drugs fail at the preclinical stage while an additional 85% fail during early-stage clinical trials, over half of which is due to previously unknown safety issues or lower efficacy than expected (Figure 2).
All six analogues were active, with the N-methylglycine analogue, [Sar7]KIIIA, the most potent in blocking the channels while favouring lower efficacy.
Background: Some comparative trials of selective serotonin 1B/1D-agonists in migraine have reported ∼15% lower efficacy for sumatriptan tablets than that reported in placebo-controlled trials.
