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Survival was not significantly different between all three treatment arms, while both chemotherapy arms showed lower distant failure rates compared to radiotherapy alone.
The patients with lower DNA-PK activity in PBLs tended to have the lower distant metastasis-free survivals than those with higher DNA-PK activity in advanced stages although the difference was not significant (P=0.08).
Also in our analysis radiotherapy alone reduced the occurrence of distant metastasis but did not reach statistical significance, whereas patients treated with radiochemotherapy demonstrated significantly lower distant metastasis rates.
The presence of extensive inflammatory infiltrate was associated with higher survival rates (p < 0.0001), lower distant recurrence rates (p < 0.0001) and lower local recurrence rates (p = 0.03) in the whole trial population (n = 1416, median follow-up = 19.6 months) (table 2).
There were more patients who are older than 64 yrs (P < 0.01), had no surgery (P < 0.01), treated with IMRT/proton therapy (P < 0.01), without a complete CRT response (P = 0.02) and had a lower distant failure rate (P = 0.01) in the AF group than in non-AF group.
RR: relative risk, Cl: confidence interval The presence of a high number of eosinophilic granulocytes, as semiquantitatively scored by the PRC, was significantly associated with higher survival rates (p = 0.007) and lower distant recurrence rates (p = 0.03) in the whole trial population (table 2).
Similar(53)
Accuracies of the best model in the cross are, however, lower for distant and unrelated breeds.
It is reported that conversion frequency is lower between distant and dissimilar gene copies [ 37, 38, 58, 59], which suggests that gene conversion is unlikely to affect the sequence homogeneity of gene families in general.
Methylation levels for most of the analyzed tumor suppressor genes were lower in distant metastases compared to their primaries, pointing to the dynamic aspect of methylation of these tumor suppressor genes during cancer progression.
The clinical profile of the study population revealed that the pattern of presenting complaint did not differ between TEM users and non-users, however, those who reported TEM use presented later, had more of ocular anterior segment pathology, and lower entry distant visual acuity.
The locus-by-locus error rate is lower for distant-related individuals and again this is because distant relatives have shorter shared IBD segments.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com