Patients who are unfamiliar with technology, live alone, or have low motivation to reach a diagnosis have a lower diagnostic yield from external loop recorders (Gula et al 2004), which limits their usefulness in the elderly.
Possible reasons for the lower diagnostic sensitivity of lipL41 LAMP compared with rrs LAMP include the difference in lower limit of detection for the two assays (10 GE/reaction and 100GE/reaction for rrs and lipL41, respectively), or infection with intermediate group Leptospira spp., which would not be detected by lipL41.
This indicates a lower diagnostic value of NewTom 3G.
GDF-15 was measured with a novel precommercial assay based on the Eclia principle (Roche Diagnostics) with a lower limit of detection (LLD) of 200 pg/mL and intraindividual coefficient of variation (CV) of 6.7 9.2%.
C-reactive protein (CRP) was measured in serum by a highly sensitive latex-enhanced turbidimetric immunoassay (Roche Diagnostics GmbH, Vienna, Austria) with a lower detection limit of 0.03 mg/L and CV of 1.7%.
Firstly the expected sensitivity values of the new diagnostic test, secondly the minimum acceptable lower confidence limit.
CL is the Laboratory Director of Multigene Diagnostics Limited, Hong Kong.
Plasma urea was measured using a colorimetric urease and glutamate dehydrogenase method with a lower detection limit of 0·5 mM (Cobas®; Roche® Diagnostics GmbH, and Mannheim, Germany).
An ELISA Kit (Diagnostic Systems Laboratories Inc., Webster, TX, USA) with a lower detection limit of 7 ng l−1 was used.
The lower detection limit of the assay is 0.01 ug/L with a recommended diagnostic threshold of 0.03 ug/L.
AGA-A was measured with an enzyme-linked immunosorbent assay (ELISA) (Phadia Diagnostic, Uppsala, Sweden) with a 10 IU/ml value as the lower positive limit.
