Other probe design strategies averaged substantially lower call rates (94.65 96.41%) and slightly lower concordance rates (99.64 99.80%).
We observed a lower concordance in the GGI prediction for the nine histological grade -2 tumors.
The heterozygous SNPs in the non-amplified gDNA showed lower concordance (average±SD, 31.4±21.1%) among S-WGA products, compared with the homozygous SNPs (82.1±11.7%, Figure 3).
Older age was significantly associated with lower concordance and this could be related to the following more rational factors that were also significantly associated with age: NAFLD, thoracic fold, waist circumference, BMI, serum glucose, ST, and AT.
Studies that have looked at HER2 status in matched primary and metastatic tumor samples have generally found concordance in the range of 90%, suggesting that HER2 status is generally stable [50], [51], [52], [53], [54], but some recent reports have shown lower concordance in the range of 60 70%, particularly when comparing between primary tumor and CTC HER2 status [25], [30], [55].
This is supported by the lower concordance with CR of self-reported lung cancer.
In contrast, interobserver agreement showed slightly lower concordance for lipid-rich plaques (κ = 0.62).
We observe relatively lower concordance for intergenic, intronic, miRNA and splicing variants.
Other studies measure much lower concordance between tumor fresh frozen and FFPE samples (92 98%) and one study comparing normal fresh frozen and FFPE samples also found lower concordance (99.4%) [ 6, 8, 9, 27].
Appraisals of relative wealth during childhood also demonstrated lower concordance, as might be anticipated for a more subjective measure.
Lower concordance in subtype assignment was observed between T1 and TS (62 %) than between T1 and T2 (75%%).
