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The older cohort had reduced hemispheric asymmetry and lower centrality of certain brain regions, such as the bilateral hippocampus, bilateral insula, left posterior cingulated, and right Heschl gyrus, but that of the prefrontal cortex (PFC) was not different.
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Second, it could be that the disease itself (i.e. the condition of the patient), leads the patient to units of lower centrality.
The TotalHill method also takes into account the neighboring links of lower centrality during the module-extension step.
Then a hill-top is either a single link with all of its outbound links having a lower centrality, or a strongly connected component (meaning that every node of the component is reachable from every other node by a directed walk on this component) consisting of all links of the same centrality with all of their outbound links having lower centralities.
The assumption of advantageous social position could equally well be linked to lower centrality, since we will focus on general trends.
G proteins, for example, have much higher centrality while ion channels/exchangers have much lower centrality.
The second level of filtering is done by filtering out those nodes which have higher degrees and a mixture of neighbors with much higher and much lower centralities.
How the centrality of the most central node exceeds the centrality of all other nodes.
The results indicate that the centrality of Cod+ genes is lower than that of a reference set (n = 1811), as clearly shown in the case of degree centrality (one-tailed Wilcoxon-Mann-Whitney test (WMW), P = 0.037), ASPL (WMW, P = 0.01), and EVC (WMW, P = 0.006).
The centrality of the ACC was significantly lower in the UHR offspring than that in the HR offspring (permutation test, p = 0.006).
Interestingly, the inset of leverage vs. degree shows that the subgroup with lower eigenvector centrality (green) in fact had slightly higher leverage centrality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com