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These data suggest that the greater weight loss observed in almond consumers may have been secondary to greater satiety and the lower bioavailability of calories from nuts.
However, this was not observed for the delta tocotrienol which has slightly lower bioavailability for GDT as compared to TRF based on the ratio of the dose given.
For example, a manufacturer whose lead product had a lower bioavailability than average would have caused less damage than its market share would indicate.
So, it is necessary to determine the metabolic profile of picroside I and II and check the correlation with lower bioavailability.
Protein from plant, as opposed to animal, sources may be preferred in chronic kidney disease (CKD) because of the lower bioavailability of phosphate and lower nonvolatile acid load.
PK results, on the other hand, revealed that the two freeze-dried AC-NPs formulations were of significantly lower bioavailability compared to Lipitor®.
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In contrast, complexation by ligands may enhance metal mobilization but often lowers bioavailability.
A group from Amsterdam postulated in The Lancet that this may be partly due to lowered bioavailability resulting from vasopressor use in critically ill patients.
In one study [ 53], individuals given 40 mg/day for 28 days of omeprazole had a 12.3% decrease in plasma vitamin C levels independent of dietary vitamin C intake, suggesting that there may be lowered bioavailability of vitamin C in patients currently prescribed proton pump inhibitors (PPI).
African-Americans have a lower cyclosporine bioavailability than Caucasians.
In addition, the mucus barrier can prevent penetration and subsequent absorption of the released drug, a phenomenon that leads to lower oral bioavailability and therapeutic concentration in plasma.
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