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Studies have demonstrated that mitochondria are maintained at a much lower activity state in MSCs compared with differentiated cells (Sanchez-Arago et al., 2013).
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Achieving remission or a lower disease activity state can be challenging, especially in patients with longer duration of RA and more severe disease activity [ 8].
When standardized to citrate synthase activity, state 3 respiration rates in permeabilized slices from IBE animals were significantly lower than isolated mitochondria (Fig. 2B).
Recently, deep power down states (e.g. C4, C5, C6, and C7) were introduced to define different levels of lower activity.
In our model, nodes can assume one of two logical states, 1 or 0, corresponding to on or off, or in more subtle instances, higher or lower activity.
This lowered activity under torpid state may be advantageous by reducing the overall energetic costs associated with protein degradation and would explain the decrease in protein catabolism in mouse lemurs in winter.
That is a sign of lower activity.
Alternatively, if the parameters are lowered past a critical point then the high activity stable state disappears in the saddle-node bifurcation instead, leaving only the low activity state.
The fall is due to lower inflation, not lower activity.
The lower activity will be observed.
This might partly explain why P-deficient leaves had lower Rubisco activity and activation state (Fig. 4).
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