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These results may explain as to why n-3 PUFAs are of benefit in the prevention and treatment of diseases such as Alzheimer's disease, schizophrenia and other diseases associated with neuronal dysfunction, low-grade systemic inflammatory conditions, and bronchial asthma.
Thus, metabolic syndrome is a low-grade systemic inflammatory condition and could be due to inappropriate cross-talk between the peripheral tissues and the hypothalamic centers implying that methods designed to restore these two abnormalities to normal could be of significant benefit in metabolic syndrome.
In response to high fat intake, a low-grade systemic inflammatory response is seen along with increased intramyocellular adipose deposition.
Several studies have conclusively demonstrated that a chronic low-grade systemic inflammatory state, predominantly arising from adipose tissue and liver, plays a critical role in the development of these obesity-related comorbidities [4] [7].
A chronic low-grade systemic inflammatory response is a defining feature of obesity [ 4].
The induction of a low-grade systemic inflammatory state is a plausible mechanistic pathway.
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These findings may echo some evidence that oral infection contributes to a low grade systemic inflammatory condition.
In fact, obesity itself may represent a low grade systemic inflammatory state and could thus favor different immune and inflammatory responses.
A potential mechanism appears to be related to systemic inflammation in which the inhalation of PM provokes a low grade systemic inflammatory response and changes in blood coagulability (Peters et al. 2001; Riediker et al. 2004; Schwartz 2001; van Eeden et al. 2001).
As altered immune function and chronic inflammation are implicated in the pathogenesis of NHL, the underlying low-grade, systemic, pro-inflammatory state associated with T2DM may, therefore, contribute to the pathogenesis of NHL 31.
Recently, it has been recognized that a chronic low-grade systemic pro-inflammatory state may influence stunting in children [ 16], which may be caused by intestinal barrier disruption and bacterial translocation [ 17].
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