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The study, which was performed from the perspective of the healthcare system, found that screening non-vaccinated women in areas with low vaccine coverage and vaccinating the susceptible was the most cost-effective with a cost/QALY of (2012) $2,300 compared to screening all women in areas of low vaccine coverage ((2012) $62,000/QALY) and screening all women in the country ((2012) $115,000/QALY).
In Slovenia, for example, a country with high TBE incidence and low vaccine coverage, the current vaccination program against TBE was found to be cost-effective for adults from a healthcare payer's perspective.
Conversely, the pessimistic scenario (low vaccine effectiveness; low vaccine coverage; 6 23 mo-old vaccination strategy) was associated with a gain of approximately 1,700 QALYs at an incremental cost of $2,200 per QALY.
However, compliance with vaccine programmes among adults is low, perhaps because of the misperception that booster vaccinations are unnecessary, leading to low vaccine coverage rates., Consequently, adults may become more susceptible to common childhood diseases such as diphtheria, pertussis and poliomyelitis and to tetanus in the case of a wound or injury.
Both studies were limited by the low vaccine coverage and the late start of the vaccination campaign.
A spokesperson for Unicef said: "Low vaccine coverage in Ukraine was initially triggered by public distrust to immunisation.
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RED is changing this, providing assistance to the 36 communes with the lowest vaccine coverage.
As the virus spread nationwide, the most affected areas were, as expected, those with the lowest vaccine coverage, mainly in southern France.
They compared the screening of non-vaccinated pregnant women in areas of low-vaccine coverage, the screening of all pregnant women in these areas, and the screening of all non-vaccinated pregnant women throughout the country.
Previously, model-based methods have been used to estimate the number of measles cases averted through targeted outbreak response vaccination in a setting with low measles vaccine coverage (2).
Prevention relies on vaccination which has several major limitations including the lag time for vaccine preparation and the low vaccination coverage rate.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com