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However, the short half-life, rapid elimination, and low tolerated dose (LD50=32.2 mg/kg in mice ) present limitations to its development as a novel chemotherapy 14, 15.
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Patients and methods: Refractory ineffective triggering was defined as persisting ineffective triggering at the lowest tolerated PSL.
The median lowest tolerated PSL was 16 cm H2O [12 18], with a PEEP level of 8 cm H2O [5.5–8] and a PaO2 FiO2 ratio of 209 mmHg [178 225].
To the extent the dracaenas tolerate low light, low water and low care, you can go ahead and get the real thing.
Moreover, transformed cells tolerated low levels of serum.
Most frogs resisted infection, or tolerated low level infections without developing clinical signs of disease.
The cortical lichens retained liquid water more efficiently and tolerated low light.
It is hypothesised that the lack of clinical benefit is due to the low exercise intensity tolerated at this time, with patients still recovering from the effects of major orthopaedic surgery.
This patient with severe hypokalemia is interesting for the following reasons: It is extremely rare that serum potassium levels decrease below 2 mmol/l and that such low levels are tolerated without cardiac arrests.
Treatment with panobinostat decreased MDA-MB-231 and BT549 tumor significantly with minimal animal toxicity, providing preclinical data on the effectiveness of panobinostat on TNBC tumorigenesis at a low and well tolerated dose.
For instance, the lowest RMR were observed in individuals from IMELOW and LOMLOW, where spawning occurred at the lowest temperatures of all the sites (apart from LAWHIGH), and this could suggest that low RMR is beneficial in tolerating low temperatures at all altitudes, particularly early in the season when temperatures can fall after spawning.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com