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However, gastrointestinal toxicity was still prominent and clinical outcomes were not satisfying due to its low tolerability.
Both unsuccessful ADCs suffered from toxicities and low tolerability, which seems to be attributed to lability of the hydrazone linker during circulation.
A proportion of chronic headache patients does not properly respond to prophylactic treatments or shows low tolerability profile and remains in need for alternative therapeutic strategies and options.
The use of lithium must be restricted to cases refractory to the other prophylactic treatments given the low tolerability in the elderly.
The main limitations to EUS reside in its invasiveness, low tolerability and costs; therefore, EUS is not routinely considered for the diagnosis of GA.
This technique has limitations due to low tolerability and difficulties in performing the procedure; therefore, single needle arthrocentesis has become more popular [86].
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Its low cost, tolerability, and availability worldwide make it a very useful tool for gynecologists.
In spite of a similar ability to inhibit tumour angiogenesis, the limited exposure of the tumour cells to PTX, due to the low drug tolerability in vivo, may account for the lack of efficacy of PTX.
Considering the patient tolerability, low cost, and lower time commitment of our simple method, clinicians can easily evaluate patellar mobility before and after treatment.
Amoxicillin has been the treatment of choice in ABS because of its general effectiveness, safety, tolerability, low cost and narrow spectrum [ 17].
Allopurinol has the main advantage of having been in the market for several decades, having generally good tolerability, low frequency of adverse events, and being rather inexpensive.
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CEO of Professional Science Editing for Scientists @ prosciediting.com