However, recent pharmacokinetic studies demonstrate that DHE metabolites measured in humans are too low to have substantial clinical effect and probably do not contribute to sustained efficacy.
In this study, however, the assumed pH25 °C of the initial solution was 4.9, which was likely too low to form substantial HCO3 − in the initial solution at room temperature.
Towards our long-term goal of tissue engineered solutions to functional tendon-to-bone re-attachment, we tested the hypotheses that partially mineralized fibrous matrices can derive toughness from mobility of mineral along their fibers, and that in such cases toughness is maximized at levels of mineralization sufficiently low to allow substantial mobility.
Here, fire and drought mortality rates are too low to compensate substantial increase in juvenile recruitment associated with high rainfall years.
The few studies that have attempted to estimate programme costs directly have shown that they vary by intervention and can range from a relatively low to a substantial proportion of total costs [ 7, 6].
For the remaining outcomes, the evidence was inconclusive at the end of the intervention, and for some outcomes the confidence in the effect estimates was very low due to substantial inconsistency in the meta-analyses as well as other factors.
Using that same rationale, while we found Spinoloricus cinziae in L'Atalante control and L'Atalante lower halocline samples, the likelihood that the same species of Spinoloricus inhabits both the normoxic, normal saline control sediments and thalassohaline lower halocline sediments is low due to substantial differences in the chemistry of bottom waters overlying sediments and pore waters.
"In advanced economies, growth is now too low to make a substantial dent in unemployment, and in major emerging markets, growth, which had been strong earlier, has also decreased".
The paleotemperatures have probably not exceeded 50°C for the Boso samples (Yamamoto et al. 2005), too low to induce any substantial mineralogical change.
This is sufficiently low to dissolve a substantial component of the heavy oil (HO) while at the same time high enough to stop dissolved salts precipitating out (Kumar and Gupta 2009).
