He was found to have normal levels of circulating T cells, but mildly low subsets of NK cells.
Furthermore, a characteristic of the tumor network not found on the normal was the existence of a small subset of low connected TFs with a remarkable contribution to minimal shortest paths (closeness centrality, see figure in Additional file 2).
The distribution of the scores for this last subscale was skewed towards the highest scores, and the lowest scores identified a small subset of students not always ranking in the lowest two quintiles of the overall score.
In general, the range of changes in gene expression was quite narrow: out of a total of 45033 transcripts, in Gelsemium s. 2c and 3c, the lowest dilutions, only a small subset of genes (577 and 165, respectively) showed |log2 fold change| > 0.5.
For perspective as a breast cancer prognostic, this ICS identifiable very low risk subset of HRneg breast cancer cases has a five-year distant recurrence risk comparable to that of the low risk group identifiable by the FDA-approved MammaPrint assay, as applied to unselected (and largely HRpos) breast cancer cases [ 34].
A low risk subset of 287 patients with SLN metastasis were followed in a non-randomized study with a 2% observed rate of local recurrence.
Most signatures identified the low-proliferation subset of ER+/HER2- tumors as low-risk, whereas almost all high-proliferation ER+, ER-/HER2-, and HER2+ tumors were classified as high-risk.
We also used a deliberately selected low-quality subset of ChIP-PET data on binding of POU5F1 to test if CisFinder can process sequences with low enrichment of binding motifs.
Importantly, MYC drives a neuroendocrine-low "variant" subset of SCLC with high NEUROD1 expression corresponding to transcriptional profiles of human SCLC.
If validated in larger studies, use of an ACI-TIPI cut point may define a low-risk subset of patients with acute chest pain amenable for outpatient management.
