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Reproducibility at low spike level ranged from 0.6 to 0.9 μg/kg and from 8.7 to 14.5 μg/kg at high spike level.
We postulated that anti-HIV-1 antibodies primarily bind monovalently because HIV's low spike density impedes bivalent binding through inter-spike crosslinking, and the spike structure prohibits bivalent binding through intra-spike crosslinking.
In contrast, the recruitment of FB inhibition sub-linearly transformed the input rate to spike output rate with high gain and low spike temporal variability, promoting the rate-to-rate code transformation.
The demonstration that intra-spike crosslinking lowers the concentration of antibodies required for neutralization supports the hypothesis that low spike densities facilitate antibody evasion and the use of molecules capable of intra-spike crosslinking for therapy or passive protection.
This training causes a side effect since, for weight increase, spike-intense patterns require a higher membrane threshold, avoiding the patterns with low spike intensity to be recognized by the network.
Unlike most of the enveloped viruses which express large numbers of closely spaced spikes on the surface, HIV virus has a low spike surface density (4 to 35 spikes) and the arrangement of these spikes is likely to be static over the time periods relevant to neutralization [14].
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Viewing figures for news channels have always been low – spiking when a big event happens.
On the left side of the line, low spikes and narrow columns.
At the low spiking level, the matrices demonstrated overestimation on the recovered values of MA.
Since the EEG does not capture the spikes and filters out the DC-component, in an experiment this would give the counter-intuitive result of high spiking activity accompanied with low amplitude EEG output, whereas, in contrast, its neighbor has low spiking activity but a markedly higher amplitude EEG output.
These include (1) the inherently high response variability of cortical neurons, (2) either very high or very low selectivity levels (intermediate selectivity provides the most robust CSI), and (3) low spiking rate.
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