Fig. 4 a Mass spectra of low specific activity FDOPA sample.
Immobilization and process recycling can compensate for the low specific activity of this preparation.
However, the 177Lu-DOTA-PEG5k-Lys-BN 177Lu-DOTA-PEG5k-Lys-BN 177Lu-DOTA-PEG5k-Lys-BN 177Lu-DOTA-PEG5k-Lys-BN 177Lu-DOTA-PEG5k-Lys-BN
The current kit necessitates an avoidable and time-consuming protein concentration step or leads to low specific activity.
Consequently, this is a possible explanation for the comparatively low specific activity of d-Hyd(co), although these enzymes catalyze two different reactions.
The lower tumour accumulation of 177Lu-DOTA-PEG5k-Lys-BN 177Lu-DOTA-PEG5k-Lys-BN 177Lu-DOTA-PEG5k-Lys-BN 177Lu-DOTA-PEG5k-Lys-BN 177Lu-DOTA-PEG5k-Lys-BN
The consequence of using FDOPA with low specific activity is that it could lead to adverse reactions such as flushes (Koopmans et al. 2006).
This fact greatly limits the applicability of the method both with species of low specific activity and in case of surfaces of industrial specimens.
By using the iododestannylation method, 123I-niodene was obtained in high radiochemical purity (>95%) but with low radiochemical yield (<5%) and low specific activity (∼100 Ci/mmol).
For the 177Lu-labelled BN analogues of low specific activity (6.6 MBq/nmol peptide), unlabelled BN analogue was added to the high specific labelling solution to reach the respective concentration.
As a consequence of the use of [18F]F2, the radiochemical yield of the radiopharmaceutical is maximally 50%% and only a product with a low specific activity can be produced.
