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This study sought to determine whether a relatively low single dose or a week-long dosage of dietary inorganic nitrate could improve exercise tolerance in patients with heart failure with preserved ejection fraction (HFpEF).
Similarly, when assessing the areas under the curve (AUC) of the corresponding arthritis score curves, a significant decrease of AA was seen after epitope specific and low single dose Etanercept combination treatment (p = 0.02 vs. no treatment).
A significant reduction of AA mean arthritis scores on day 23 (p = 0.0004) was achieved with epitope specific and low single dose Etanercept combination treatment as well as with a full course of Etanercept therapy (p = 0.004) compared to no treatment.
Hence, regardless of the outcome parameter employed, combination of epitope specific and low single dose Etanercept therapy enabled complete clinical control of the arthritic process to a degree statistically comparable with full dose Etanercept, a therapeutic regimen known to fully control AA.
Moreover, the addition of a very low single dose of PKI-587 (0.5 n M) with increasing doses of cetuximab enhances sensitivity to the latter in both resistant Detroit562 and Kyse30 cells (Supplementary Figure S1).
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In a randomized crossover study 27 nondiabetic smokers and 16 nonsmokers received relatively low single doses of 33.8 IU inhaled insulin AERx iDMS (Himmelmann et al. 2003).
To evaluate the effectiveness and safety of postoperative low single-dose of beta-irradiation (β-RT) in pterygium comparing conjunctival autograft (CAG) surgery with CAG plus adjuvant β-RT in a randomized clinical trial.
This study investigated the antioxidant and renoprotective effects of SNE in T2DM rats induced by high-fat diet with low-single dose streptozotocin.
T2DM in rats was induced by a combination of high-fat diet (60% fat of total energy) ad libitum and low-single dose of STZ intraperitoneal injection (40 mg/kg BW) as previously described [ 27, 28].
There are reports showing no evidence of HPA suppression in any of the patients who received a low single daily dose of GC treatment, even when the dose was given at bedtime [ 25, 36, 37].
C60FAS, without showing direct cytotoxicity, cause at low single therapeutic dose (5 mg/kg) antitumor immune response.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com