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Applying the assumption that the genes exhibiting temporal changes are potentially related to the outcome, we next excluded those probe-sets with a 'low' sample coefficient of variation, which we defined as having a coefficient of variation in the bottom half of the sample (i.e., below the sample median).
Although coefficients of variation of estimated detection probability (ˆp) and cluster size (ˆE(S)) were higher at low sample sizes, they dropped to <15% with n > 40 detections.
In this sample, coefficient alpha was.94.94
In our sample, coefficient alpha was.92.92
Through sliding window analysis, we found that regions with high genetic sequence divergence also have high CG methylation divergence (low correlation coefficient) among samples.
In order to find those genes having both a high number of reads and a low variation coefficient among samples from different phenological stages and conditions, pseudo data sets were simulated by resampling of the original data.
Ikaris et al. ([2011]) found experimental evidence for the relationship between the weakness of rocks and their frictional stability: rock samples with a low friction coefficient show velocity-strengthening behavior, whereas samples with high friction coefficients show velocity-weakening behavior (Figure 1).
The ion beam-sputtered silicon dioxide film resulted in a dramatic reduction of specific wear rate in each sample, accompanied by low friction coefficient.
These authors suggested that the extensive RNA sample degradation in FFPE samples is likely the cause for the low correlation coefficients observed across sample pairs [ 13].
The measured samples have a quite low correlation coefficient between δ13CPDB and δ18OPDB (r = 0.46) which would imply a generally open setting, where fresh sea water was commonly introduced.
Immunohistochemical staining data and sHE4 levels showed a low concordance coefficient in paired tumour samples.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com