The overlap is surprisingly low, especially on reaction level, where the databases agree on 3% of the 6968 reactions they have combined.
However, the consensus on reaction level remains low even for this more limited set.
Using a relatively stringent significance level (FDR = 0.005) for selecting significant probe sets, we identified 4,982 and 8,952 significant probe sets that were differentially expressed between the amygdala and hippocampus samples in the low and high reaction levels in the GSE4035 data set.
The results of this study show that the data overlap of networks reconstructed with different databases, especially at the reaction level, was surprisingly low and therefore, the level of database agreement is deemed to be low as well.
However, also for the TCA cycle the consensus on reaction level is surprisingly low, although higher than what was observed at database level.
Especially on reaction level the overlap is surprisingly low, only 199 reactions could be found in all five databases.
It may be noticed that when contour peak attains a lowest level, reaction dominates over diffusion and peak moves upwards to attain its original height.
Whereas, excluded reactions with a low confidence level were excluded only due to their low expression level.
A likely implication may be that even an established but untransplanted viral tumor, such as the Kaposi sarcoma, remains dependent upon a long continuing, stimulatory, low level immune reaction.
