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The FDA SEALD cites limitations specific to the current Ra-223 application including small number of assessments (maximum of 4 for FACT-P), low rate of completion at week 24+ as well as a small observed magnitude of treatment effect.
On the other hand, the low rate of completion (40.7%) recorded in this study, highlight the need for a careful patient selection and eventually, for a tailored surgical and medical approach.
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Time constraints were cited as the main reason for low rates of completion.
Despite timely PEP initiation, low rates of completion negate its intended benefits.
Previous studies have shown high potential demand for PADs but low rates of completion in the United States, despite new laws authorizing PADs in over 20 states.
For example, there are urgent questions to be addressed by policy makers regarding the lack of access to quality palliative care and the low rates of completion of valid and useful advance directives.
Low levels of literacy, low rates of completion of primary and secondary school education, poor access to justice for survivors of sexual violence, and high rates of early marriage were outlined in a previous publication focused on sexual violence findings of this study [ 17].
Questions with the lowest rate of completion were on hearing loss (94%), vision (92%), and age when mother was last in full time education (92%).
We omitted this test for pragmatic reasons: an accurate diagnosis of definite AD according to Ewing's classification can be made based on 3 HR tests; this test had the lowest rate of completion in Walsh and Nelson's earlier study, as participants found it difficult.
Also worth discussing is the shockingly low rate of college completion among these students due to lack of financial resources, but the focus here is on the following scenario: a bright and driven young woman receives a coveted acceptance letter accompanied with a break-down of financial aid.
Just take one of the most repeated attacks against MOOCs: their incredibly low rates of course completion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com