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Cells with high Rac, but low RhoA, are more migratory, while cells with high RhoA, but low Rac, are less migratory.
Ratiometric FRET imaging at 1 s frame intervals showed that high Rac activity correlated spatially with lamellipodial protrusions and low Rac activity with membrane retractions.
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Therefore, Raichu-Rac protein levels are low compared to endogenous Rac, as we had aimed for, in order to prevent possible dominant-negative effects.
Finally, the PTGER4 rs76523431 variant has a low MAF (HCSC-RAC 1.8 %, PEARL 4.3%%, PAZ 1.2%%, EAC 2.1 %, NDB 2.0 %, and Wichita 1.5 %), and therefore it has a lower power to detect weak effects than loci with higher MAFs.
Low regression coefficient of RAC with SF is observed in the short-term.
The interaction of FilGAP with FLNa emerges as a key factor in maintaining low levels of active Rac in mechanically challenged cells 25, while ECT2 is capable of mediating GTP exchange on Rac1 during mesenchymal migration and invasion 26.
Figure 1 shows that glucose release was greatest from enzymatic hydrolysis of RAC and lowest from Avicel cellulose at the highest and lowest enzyme loadings applied in this study over almost the entire hydrolysis time.
Gao et al. reported that a low molecular weight inhibitor of Rac GTPase targeting the activation of Rac by GEF was able to reverse the tumor cell phenotype associated with deregulation of Rac [ 14].
According to chloride diffusion results, high RCA content lead to an improvement of durability in RAC with sufficiently low w/c ratio, in terms of chlorides presence.
However, RAs can bring about several performance decreases when they are used for recycled aggregate concrete (RAC) because of the low qualities (i.e., high water-absorption rate and low density) caused by the attached hydrated cement paste on the RA surface.
The high and low standard dilutions also contained rac-Tocol (internal standard) at 5 µg/mL and 1 µg/mL, respectively.
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