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The in vitro model systems that are currently employed to screen the permeation characteristics of a drug often represent a compromise between high throughput with low predictive potential and low throughput with high predictive potential.
These analyses suggest that the small number of genes in the TFSVM training set and perhaps existence of significant fraction non- representative members in that set assure that the method has low predictive potential.
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Natural cubic spline interpolation produced relatively smooth curves but had low predictive accuracy and high variability in potential cumulative CO2 flux values (between 528% and − 617%).
Indeed, Baldus et al. [ 8] reported prognostic potential of MPO in those with low or medium troponin T elevations, with poorer predictive potential in those with high troponin T levels.
The number of known occurrences in our study was low (n = 22) and many studies note that small sample sizes can significantly reduce the predictive potential of models [ 31, 61- 63].
A low rSec62 value predicts increased survival of NSCLC patients, with an even stronger predictive potential for SCC patients.
Metabolic reconstructions of other mammals will be of insufficient quality and predictive potential using the presented approach due to the low number of homologous genes with Recon1 genes.
Although only a low number of patients were used there was some suggestion of potential prognostic and predictive potential of these signatures.
Recent reviews have demonstrated the low predictive value of preclinical testing in identifying novel pharmaceutics likely to have therapeutic benefits, as well as in detecting potential adverse effects early in drug development (Krauth et al. 2014).
Sporn, J.C. & Jung, B. Differential regulation and predictive potential of MacroH2A1 isoforms in colon cancer.
Opinions about HSX's predictive potential often follow generational lines, said one midlevel manager at a major studio who did not want to be identified.
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