Sentence examples for low objective response from inspiring English sources

In conclusion, CL56 has a low objective response rate in the management of absolute hormone refractory prostate cancer.

Clinical results with ipilimumab are characterised by low objective response rates, usually below 20%, but frequent long-term responses.

As a single agent, temsirolimus displayed a relatively low objective response rate of 7%, with 26% additional minor responses (Table 1).

In this group of relatively unselected patients, we have confirmed a relatively low objective response rate and median survival of 7.8 months with this regimen.

We found comparatively low objective response rates and a comparatively high proportion of patients with minor response and disease stabilization, qualifying for SD.

Moreover, antiangiogenic treatment faces currently some other challenges, such as low objective response rate and a huge economic burden of the high price [ 4, 10].

Gemcitabine as a single agent is considered to be the standard treatment for these patients since, in spite of the low overall objective response, studies have shown an improvement in overall survival and a statistically significant clinical benefit when compared to the best supportive care (Casper et al, 1994; Burris et al, 1997).

A large phase II study concluded that the clinical value of single-agent trastuzumab in recurrent ovarian cancer is limited by the low frequency of HER2 overexpression and low rate of objective response among patients with HER2 overexpression [ 86].

Single-agent TKIs have low objective rates of response, which are usually less than 50% in the selected patients [ 10, 31].

Due to the low rate of objective response (n = 4), analysis of potential predictive factors was carried out by categorizing patients as having either a clinical benefit (Complete response, CR; partial response, PR; and stable disease, SD; n = 15), or progressive disease (PD; n = 60), as previously described for this patient cohort [ 23].

In the presence of pulmonary metastases, locoregional administration of inhaled-IL-2 was reported to yield low toxicity combined with objective response rates of pulmonary disease of 2.5 21% (Lorenz et al, 1996; Merimsky et al, 2004).