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While it is known that high life expectancy is associated with low lifespan variation, we wanted to establish whether life expectancy leaders had the most egalitarian lifespan distributions.
These findings make clear that the correlation between high life expectancy and low lifespan variation is due to progress in reducing premature mortality.
8 We use this new formula and apply it to a large dataset on developed countries to gain a deeper understanding of the relationship between high life expectancy and low lifespan variation.
2 The negative correlation between high life expectancy and low lifespan variation has been investigated for several countries, including the USA, 4 6 7 England and Wales, 7 Sweden 6 and Japan.
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The 10% of mutants with the lowest lifespan scores are provided in Table S4.
Interestingly, the intermediate bacterial level, 6 × 10 cells/ml, where we observed the lowest lifespan, also showed a heightened accuracy.
Bokov et al. predicted a 'stressor' that would explain the comparatively low mean lifespan of our 129S2 controls.
To better address how decline in serum IGF-1 affects aging, we used two mouse models: (i) congenital liver IGF-1-deficient (LID) mice, where serum IGF-1 is low throughout lifespan, and (ii) an inducible liver Igf1 gene-deleted (iLID) mouse model (Wu et al., 2010; Courtland et al., 2011), which allows temporal control of IGF-1.
Range is defined by the difference between the highest and lowest mean lifespan response across the six food levels.
Virgin mir-317D females showed a steady decline in survival from day 20 onward, resulting in the lowest maximum lifespan (∼60 days compared to ∼70 days for the other female genotypes; Figure 3C).
Consistent with that possibility, offspring from humans with long lifespan have low levels of PUFAs in the membranes of erythrocytes (Puca et al., 2008).
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