Sentence examples for low levels of receptor from inspiring English sources

Since the low levels of receptor expressed in monocytic cells precluded us from performing immunoprecipitation studies in those cells, we attempted to visualize the distribution of CCR2 and FLNa proteins in two human monocytic cell lines, Mono Mac 1 and THP-1, which endogenously express the CCR2 receptor [9] by immunofluorescence.

These responses could not be predicted by the presence of receptors, since in some cases no signaling could be observed in response to a certain cytokine despite expression of its receptor, while in other cases relatively low levels of receptor expression correlated with a strong cytokine-induced STAT5 response.

Low levels of receptor expression seem to have a negative effect on survival and are unrelated to other pathologic variables.

GPCR-GFP fusions can also overcome problems of relatively low levels of receptor expression, the stoichiometry of the receptor and the fluorescent protein is well defined.

The importance of SORLA for AD is further supported by low levels of receptor expression seen in patients suffering from the disease [ 12, 13].

This observation suggests that cells expressing low levels of receptor needs to produce high levels of ligand, supporting the importance of this autocrine pathway in MM, a possible therapeutic target.

We generated astrocytoma subclones that express set levels of CB1 and CB2, and found that cannabinoids induce apoptosis only in cells expressing low levels of receptors that couple to ERK1/2.

The intake of bacteria is compromised in neonates either due to decreased levels of opsonized proteins or/and to low levels of receptors involved in phagocytosis [ 6, 10].

Tumours with detectable EGF receptor often had low levels of oestrogen receptor.

All the tumours that did not contain oestrogen receptor mRNA and most of the tumours that contained only low levels of oestrogen receptor mRNA were classified as grade III according to Bloom and Richardson: the median of the oestrogen receptor mRNA levels was significantly lower in this group.

Studies have demonstrated that DU145 cells are negative for androgen receptor due to promoter methylation [ 55] or express low levels of androgen receptor [ 56].