Sentence examples for low level gain from inspiring English sources

Clone E8 showed low level gain of FGFR1, also consistent with the array CGH results (Supplemental Figures 1 and 4).

It is also possible that other genes mapping within 2p2 e.g. Id2 may be the targets for low level gain in this region.

Recently, Hashimoto et al (2001) have further delineated the involvement of 3q gains in HNSCC tumorigenesis by demonstrating a correlation between amplification, as opposed to low level gain, of 3q26 qter and tumour progression.

While FGFR2 is not amplified in any of the five TNBC cell lines, all of the five cell lines showed overexpression of FGFR2 with one of the cell lines exhibiting a low level gain of a region encompassing FGFR2 (HCC1937).

Low level gain was defined as a smoothed Log2 ratio of between 0.12 and 0.40, corresponding to approximately 3 5 copies of the locus, whereas gene amplification was defined as having a Log2 ratio >0.40, corresponding to more than 5 copies (Arriola et al, 2008).

The third group (n = 39, Figure 3A, right branch) comprised of both ER positive and negative tumors is characterized by the presence of low level gains and losses and recurrent amplifications.

Application of array CGH to the analysis of copy number aberrations in 62 sporadic ductal invasive breast tumors and five BRCA1 mutant tumors revealed a number of frequent low level gains and losses (Supplementary Tables 1 and 2, Additional files 1 and 3) and 12 regions of recurrent amplification (Table 1).

The "mixed amplifier" group had low level gains and losses with some recurring copy number changes, while the others two types had either few copy number changes ("1q/16q" group) or significant changes encompassing nearly 60% of the genome with copy number alterations ("complex" group).

We determined the number and type of copy number changes in each tumor by counting three types of copy number alterations; copy number changes involving whole chromosomes, low level gains and losses affecting extended portions of chromosomes, and amplifications defined as focal regions of increased copy number [ 14].

The most frequently targeted gene by low-level gain is GAB2 (30%).

The peak identified by GISTIC contained the gene BRD4 and was the highest by low-level gain frequency.