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This review identified only 4 studies providing low level evidence on the effects of static and dynamic post-operative splinting.
Clinical consensus has been used widely to establish guidelines for the effective use of diagnostic imaging in several countries but confers only low level evidence for cost-effectiveness.
Recommendations for fascial therapy are few and of low level evidence but several studies indicate strong correlations between fascial thickness and low back pain.
However, apart from low level evidence base recommendations for myeloma patients receiving thalidomide and linalinomide, there is no clear evidence-based guidance regarding thromboprophylaxis.
33 Lastly, the availability of good quality low level evidence may limit the feasibility of randomisation, a control group and blinding, since this influences both patient and clinical equipoise.
As a conclusion, sound evidence of most if not all cell death modes is available in renal cellular models, but very weak and low level evidence is available from in vivo studies and human tissue.
Similar(52)
Two publications with low-level evidence were found [28, 29].
Methodological requirements differed mainly in the acceptance of low-level evidence, surrogate endpoints, and data modeling.
Little data on this topic in the ICU are available, suggesting limited efficacy in this setting [72, 138], and it was obtained from studies with low-level evidence.
Two low-level evidence studies specifically demonstrated a potential benefit of aminoglycosides in critically ill patients with neutropenia and severe sepsis and/or septic shock [126, 127].
Although all of these reports are of low-level evidence, they suggest that, along with the remaining uncertainties regarding G-CSF benefits in ICU patients, G-CSF should be stopped in high-risk patients in the days preceding neutropenia recovery.
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