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Thus, one can make comment that none to very low inhibitory effect of the AL extracts in the enzyme inhibition assays are likely associated with the absence of flavonoid derivatives such as quercetin (Table 2).
Intriguingly, each single deletion mutant vector exhibited a low inhibitory effect on luciferase activity compared with the Wt vector after Pre-miR-126 co-transfection (Figure 3B).
Furthermore, FLLL-11 and FLLL-12 had a low inhibitory effect on cell viability in WI-38 human lung fibroblasts.
At the concentration of 100 μg/ml, MEMM showed high inhibitory activity against the lipoxygenase assay, but low inhibitory effect against the xanthine oxidase assay (Table 5).
Since a synergistic effect was expected, both the agents were used in the concentrations of a low inhibitory effect on proliferation of Panc-1 cells.
Methanol leaf extract showed significant low inhibitory effect against tested fungus Trichophyton ajelloi MTCC 4878 (0.140625 mg/ml) as the most sensitive.
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These compounds are supposed to have no or low inhibitory effects on NF-κB or AP-1 activation.
PrTX-III chemical treated with aristolochic acid and p-BPB, two standard PLA2 inhibitors, showed low inhibitory effects when compared with the HP-2 treatment.
In contrast, all the extracts had low inhibitory effects on the growth of A549 suggesting the resistance of this cell line towards the tested samples.
Whereas the lower concentration of TNF-α revealow low inhibitory effects on gene expression of α-SMA and collagen type I, the expression of these two transcripts was significantly downregulated upon addition of 10 ng/mL TNF-α.
Dasatinib induced a concentration-dependent decrease in cell proliferation: it had no effect at the lowest tested concentrations (10-9 and 10-8 M), had low inhibitory effects between 10-7 and 10-5 M and was clearly toxic at 10-4 M (Fig. 4A), with morphological evidences of necrotic cell death (data not shown).
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