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Crimmins and Finch [ 43] even suggest that the genetic polymorphisms responsible for a low inflammatory response in humans might result in a greater chance of longevity.
The material shows a low inflammatory response which is accompanied by the formation of a fibrous capsule, reflecting the inertness of the material.
Despite an acceptable and low inflammatory response, preincubated aortic fragments accelerate early angiogenesis of tissue-engineered constructs; the angiogenesis was found to occur faster than that observed in previous studies.
The poor sensitivity of this technique in low-grade infection is probably due to the low inflammatory response caused by coagulase-negative staphylococci, the organisms most commonly infecting TKA [7].
These results correspond with the previous analyses showing low inflammatory response in MMP19−/− mice and point to a biased distribution of T cells at the inflammatory site.
Therefore, the low inflammatory response observed in gal3−/− mice may be derived from the enhanced TLR2 expression and elevated IL-10 production in macrophages stimulated by the fungal antigens.
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On behalf of their use for medical purposes these biomaterials should cause only low inflammatory responses and have no or negligible antigenicity and a good stability in vivo.
Moreover, PMMA may be a biocompatible material with similar low inflammatory responses with PDMS, which is already known to be safe in the bladder.
The strongest angiogenesis and lowest inflammatory response were observed in Group I. Average capillaries density was 2.75, 0.75, and 1.53 and inflammatory effect was 0.29, 1.39, and 2.72 for Groups I, II, and III, respectively.
Hence, these cytokines play an important role in the low-inflammatory response of OA.
A low grade inflammatory response as a consequence of low concentrations of microbiota have been shown to accelerate wound healing (Häkkinen et al. 2000).
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