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The 'moderate decreasing pain class' (32.5 %) was comprised of girls showing moderate to rather low headache frequencies across time, with significant changes.
We can suppose that in our patients a low headache attack frequency may reduce the proximity and the attention from the caregiver, thus it can lead the separation anxiety feelings to be increased.
As a population-based sample was analysed, one large class with no or a very low headache frequency over the whole assessment time, for both boys and girls was expected.
Headache-related disability was highest in patients with high headache frequency with/without medication overuse or psychiatric comorbidity (modules 2/3) compared to patients with low headache frequency and medication (module 0).
The fourth class of girls (16.2 %) was defined by a low headache frequency at first wave, with a significant acceleration that stabilised by the time of the fourth wave (s = 19.143, p < 0.001, q = − 3.303, p = 0.005; class 2: 'increasing pain class').
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When the results of our analysis (Fig. 3 ) are considered, one would expect that a majority of subjects selected at any high monthly headache-frequency value would, within three months, have a period of low headache-frequency suggesting that the high placebo rate may be, at least in part, an artifact of inclusion criteria interacting with the natural history of headache frequency.
When your blood sugar levels get too low, headaches are a common side effect.
The overall incidence of AEs was low and headache and epistaxis were the most common individual AEs reported.
Most patients (55.1 %) had low frequency headache attacks, whereas 44.9 % complained of high frequency episodes.
The number of drug-related adverse events reported after ritonavir alone was low, with headache and fatigue being the only two adverse events reported on more than one occasion.
The number of drug-related adverse events reported following metoprolol alone was low, with headache and fatigue being the only two adverse events reported on more than one occasion.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com