Your English writing platform
Discover LudwigExact(3)
The values in the biologically high grade group 2 were significantly lower than either of the two low grade groups 1 and 3, with P values of 0.0001 and 0.0001, respectively.
Among all-WT patients of KRAS, BRAF, NRAS, and PIK3CA, the median PFS in the high grade and low grade groups were 8.0 months (95%CI, 5.4 10.6) and 2.5 months (95%CI, 0.0 5.4), respectively.
In addition, the median OS of the high grade and low grade groups were 14.6 months (95%CI, 12.0 17.3) and 7.1 months (95%CI, 5.6 8.9), respectively, and there was a significant difference in the OS between these two groups (P = 0.001).
Similar(57)
These may be divided into usual type (70%), highly aggressive basaloid (10%) and a slow growing, low grade group of 'verruciform' tumours (20%) [4].
Median OS in the high grade group and low grade group were 17.6 months (95%CI, 11.5 23.7) and 7.1 months (95%CI, 5.3 9.0), respectively.
When patients were divided into groups according to grade, the median PFS in the high grade group and low grade group were 6.4 months (95%CI, 4.8 8.0) and 2.4 months (95%CI, 1.6 3.3), respectively.
Interestingly, the local control rate was considerably lower in the high grade tumor group when compared with low grade group following postoperative radiotherapy (local failure rate 22.7% vs 55.6%, P = 0.08).
We categorized the tumor grading into 3 groups: a high grade group consisting of Gleason 8 10 or poorly differentiated adenocarcinoma, an intermediate grade group consisting of Gleason 5 7 or moderately differentiated adenocarcinoma and a low grade group consisting of Gleason 2 4 or well-differentiated adenocarcinoma [ 2].
Both gene expression-wise and with regards to prognosis approximately two-thirds of G2-tumors are similar to the low grade group whereas about one third resemble the high grade group [ 7, 8], which means that 40-50% of breast cancer patients currently get an unnecessarily imprecise estimate of their risk of recurrence.
It should be noted, that nuclear and cytoplasmic YB-1 expression in the high and low grading groups G3 vs G1 has not shown statistically significant correlation with DSS.
In the low-grade group, NMP22 and FISH analyses were more sensitive than cytology, but in the high-grade group, all three methods showed approximately 90% sensitivity.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com