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low effect level.
The concentration (low effect level, LOEL) is based on an interdisciplinary European project in which the cytotoxic potency of a variety of particles was analyzed with different cell types under submersed culture conditions [ 21].
It is possible that arsenic concentrations in the Danish drinking-water are below a low effect level; however, the results of the present study cannot rule out a weak adverse effect that is impossible to detect with the method used and the study size.
Here omic approaches may provide insights on low effect level metabolic dysfunctions which may have implication over a life-time exposure, but may not be revealed in the time-limited chronic bioassays that form a cornerstone of modern chemicals policy [ 77].
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These toxicity values consist of many different dose measures captured at either the study or chemical level, and include measures such as PODs, LOALs or LOAELs, NOALs or NOAELs, No effect or Low effect levels (NEL or LELs), cancer-related quantities (cancer slope factors, inhalation unit risk), and other derived quantities such as RfDs and EPA Regional Screening Levels [86].
For combinations acting through nonsimilar pathways, RDA approximates IA at low effect levels.
Assuming that the costs are constant, a change in effect will be different for low effect levels than for high levels.
If analysis is limited to low effect levels (when the product term in Equation 8 is negligible), or in the rare case of linear response, the toxicologic (IA) and epidemiologic (RDA) approaches reach the same conclusion.
LEL, lowest effect level; SEL, severe effect level; ERL, effect range low; ERM, effect range median.
It is important to determine whether the estimated concentrations of heavy metals in sediments pose a threat to aquatic life, and they are assessed by two sets of sediment quality guidelines: (i) lowest effect level (LEL) and severe effect level (SEL) and (ii) effects range low (ERL) and effects range medium (ERM) (MacDonald et al. [2000]).
Results based on strong extraction, using concentrated acids, revealed that the Lowest Effect Level (LEL) for As, Cd, Cu, and Hg was exceeded at more than 75% of sampling sites and the Severe Effect Level (SEL) for As at 16.2% of sites.
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