Perhaps the strongest evidence for unique low-dose-dependent signaling is the finding that some phosphopeptides undergo very large changes only in the 2-cGy treated cells making it unlikely that these changes are due to random chance.
Among the Krakow cohort, cord cotinine was low, but dose dependent (0.15 ± 0.32 among nonsmokers vs. 0.84 ± 1.60, 0.92 ± 0.93, and 2.62 ± 3.42 ng/mL, among those with one, two, or three smokers at home, respectively) based on the third-trimester questionnaire (Spearman's rho = 0.391, p = 0.006).
Taken together, our results confirm that increased keratinocyte proliferation following treatment with low dose VD3 is dependent on VDR-mediated regulation of ΔNp63 α expression.
Moreover, in a rat model of cholestatic liver disease where plasma ectonucleotidase activity is enhanced, reduced aggregation was exhibited in response to ADP and low dose collagen (which is dependent on ADP secretion) (Witters et al, 2010).
To verify that increased cell proliferation following low dose VD3 treatment was dependent on VDR-mediated regulation of ΔNp63 α expression, we generated HaCaT stable cell lines expressing ΔNp63 α (HaCaT-ΔNp63 α) or eGFP (HaCaT-eGFP) as a control.
Further, 13 nm AuNPs at low dose (0.2 2 nM) showed dose-dependent cytotoxicity in rabbit articular chondrocytes (Fig. 2a).
7 8 Older literature has suggested that MTX toxicity is dose-dependent and low dose MTX monotherapy treatment can be effective.
Results showed that stimulation of the AR pups reversed the effects of artificial rearing on apoptosis in a dose dependent manner; low and very high levels of stimulation were without effect whereas moderate levels of stimulation produced effects on apoptosis similar to effects seen in mother-reared controls.
These mechanisms are likely to be dose dependent with low gemcitabine doses preferentially inhibiting viral replication and higher doses inhibiting both viral replication and cell proliferation.
The response to A12 was dose dependent, with low doses being more effective than high doses.
