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This work evaluates the wet agglomeration process of maltodextrins of different degrees of dextrose-equivalent, DE 5 20, following a sequential strategy of experimental designs in order to produce granules with low dissolution time.
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For the solids with high XPb or low XCa [(Pb0.89Ca0.11 5(PO4)3OH], the aqueous Ca2+ concentrations increased gradually with the dissolution time and achieved a stable state after 4320 h dissolution.
The economic benefits of OES pretreatment include: 1) reduced costs of IL (for example, 70% [AMIM]Cl), 2) less energy required for stirring and transporting of the mixture, owing to the low viscosity of the OES, 3) higher throughput because of the shortened dissolution time, and 4) environmental benefits from the reduction of gas, water, and solid wastes.
Mean dissolution time.
A striking experimental observation is that below a critical particle size, the dissolution time does not depend on the particle dimension, a finding that is in sharp contrast to the dissolution of ordinary low molecular weight systems.
Pore depth was linearly dependent on the dissolution time.
Azithromycin, as a kind of hydrophobic drug, has a low bioavailability of about 37%% due to its low dissolution rate.
This category relates one dissolution time point (t50%, t90%, etc).
The mean in vitro dissolution time is compared to either the mean residence time or the mean in vivo dissolution time.
The mean in vitro dissolution or release time is compared to either the mean residence time or the in vivo mean dissolution time.
The dissolution efficiency is the highest, i.e., 37 48% and mean dissolution time is the shortest, i.e., about 8 min for samples S4 and U7.
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