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In Figures 1, 2, and 3, we do not estimate target concentrations for spike-ins in the low concentration category.
While our method yielded excellent predictions of absolute transcript concentration, we did not predict concentration for all transcripts in the low concentration category (Fig. 1 and 2).
In addition, a sensitivity analysis, in which newborns from cities and towns where groundwater was not tested were classified into the low concentration category, did not significantly change the study findings.
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The SMR in the lowest concentration category was significantly elevated, suggesting a difference between respiratory cancer mortality rates for U.S. males and a hypothetical group of nonexposed workers.
For current asthma, we fit logistic regression models by quartile concentration categories of the metabolites (lowest concentration category as reference) and a second model with phthalate metabolites as continuous variables (log10-transformed).
The low-concentration category consisted in concentrations > 50th percentile (12.2 μg/m), the intermediate-concentration category in concentrations between the 50th and 75th percentiles (between 12.2 μg/m and 16.2 μg/m), and the high-concentration category in concentrations ≥ 75th percentile.
And in most cases, the low-concentration categories will require a much larger marketing investment to achieve liquidity.
But when 10 equal groupings were created the trend seen in the quintiles remained, with a linear decline in odds ratios from 0.96 (CI 0.74 1.20) in the second lowest radon concentration category to 0.46 (CI 0.34 0.62) in the highest concentration group, with the six highest groups showing statistically significant negative risks.
As compared with the low risk blood glucose concentration category, intermediate risk concentration category and high risk category were associated with hazard ratios for death of 2.88 and 4.6, respectively.
"So yes, to an extent, the low concentration is somewhat protective in that the total daily dose will be low".
Results for each cancer type are presented for high concentrations of 25(OH D (defined as either ≥100 nmol/L or ≥75 nmol/L, depending on the number of cases for a specific cancer type) versus the reference category (50 <75 nmol/L) and for low concentrations of 25(OH D (defined as either <25 nmol/L or <37.5 nmol/L) versus the reference category.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com