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The added value of QFT-GIT in PLWHA has been explored in other countries with low burden and incidence rate of TB (Spain and USA), with variable findings.
Both clinical dogma and the societal perspective on costs encourage a diagnostic strategy that combines a high yield with low burden and costs.
46 We do not expect the association between low burden and subclinical disease with SRH to be time dependent to the extent that it would change our results considerably.
This means combining a high level of user-friendliness (ie, short and rapidly completed tools with low burden and easy interpretation) with strong and explicitly stated measurement properties to support decisions at the level of the individual patient.
The ceiling ratio for QALYs gained in the Netherlands is also not established, but it has been proposed to be set at €8000 for diseases with a low burden and at €80,000 for diseases with a high burden [ 30].
An adjusted version of the Dutch Flemish WAV-12 to assess the parent-team alliance in youth residential psychiatry may be a useful, low burden, and an accurate instrument to be part of a routine monitoring system.
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Studies from other hospitals in low burden settings and in South Africa have shown that next generation sequencing (NGS) is a very powerful tool for rapidly sequencing whole TB genomes and comparing them to confirm or rule out nosocomial transmission.
There is increasing evidence that IGRAs perform differently in high burden compared to low burden countries and this may partly explain the differences seen amongst the different studies[21].
Additionally, we found that clinical condition of seriously ill patients often changed rapidly; the two selected post-consultation items were of very low burden cognitively and emotionally for participants to complete.
This has a low-burden, and was designed to assess short-term fluctuations in anxiety.
Pulitano et al. [3] concluded that the total number of metastases implicated tumor biology, and different survival was found between low-burden and high-burden metastases.
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