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Thus, risk factors for wheezing and asthma or low airway function in childhood might predispose for respiratory diseases in later life.
Examples of known major risk factors in early childhood for development of respiratory disease or low airway function include exposure to parental smoking or air pollution, no or shorter period of breastfeeding, obesity, larger family size, daycare attendance, infectious diseases in early childhood and acetaminophen use [ 49– 56].
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Air pollution may increase airway oxidative stress and decrease small airway function of asthmatic children.
The expiratory flow rates pertaining to large and medium airway function improved, but those for small airways remained low.
Taken together, these results indicate that even low-to-moderate levels of ETS exposure may have deleterious effects on airway function and obstructive lung disease.
Interestingly however, at 10d post-siRNAITSN treatment, the pulmonary function of KDITSN mice evolved toward increased CL, increased IC and low airway RL, compared to the wild-type or 72 h post-siRNA mouse lungs.
The lowest doses of revatropate and ipratropium induced a rapid (within 1 h) and significant improvement in airway function.
Conclusions: Airway function during the first year shows considerable tracking.
These results demonstrate that RSV persistent infection induces significant alterations in the peptidergic innervation in the airways, which may be associated with the development of altered airway function.
However, it is not known how each of the many structural changes that occur in the airway wall contributes to altered airway function in asthma.
Torres, R. et al. An intranasal selective antisense oligonucleotide impairs lung cyclooxygenase-2 production and improves inflammation, but worsens airway function, in house dust mite sensitive mice.
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