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A low adulthood SEP was associated with an increased risk of CVD mortality among both men (HR 1.84, 95% CI 1.41-2.39) and women (HR 1.80, 95% CI 1.04-3.10).
In contrast, among women, two adverse psychosocial factors (i.e. having experienced 2≥ negative life events, and depression/nervousness) were more prevalent among those with a high adulthood SEP, but among men, adverse psychosocial factors were more prevalent among those with a low adulthood SEP.
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For instance, the reduction in the OR for the lowest adulthood SEP group when adding childhood socioeconomic conditions to the first model, is [(1.84-1.71)/(1.84-1.00)]*15% = 15%.
For instance, the reduction in the OR for the lowest adulthood SEP group when adding childhood SEP to the first model, is [(1.80-1.71)/(1.80-1.00)] * 100 = 11%.
Childhood socioeconomic conditions were most important for explaining the increased risk of dying from CVD among men with the second lowest adulthood SEP (12% directly, and 7% via adulthood risk factors).
Simultaneous adjustment for adulthood risk factors and childhood socioeconomic conditions attenuated the HR for the lowest adulthood SEP to 1.34 (95% CI: 0.99-1.82) for men and 1.19 (95% CI: 0.65-2.15) for women.
When material, behavioural and psychosocial factors were all included (model 6), the HR for the lowest adulthood SEP reduced by 52% (CI: -94% to −33%) among men, and by 73% (CI: -230% to −34%) among women.
This model was further adjusted for childhood socioeconomic conditions (model 7), which led to a total reduction of the HR among those with the lowest adulthood SEP of 60% (CI: -109% to −32%) among men and 76% (CI: -232% to −29%) among women.
The highest risk for CVD mortality as observed among those with the lowest adulthood SEP (model 1) reduced insignificantly by 15% (CI: -40% to 5%) for men and 11% (CI: -74% to 31%) for women when childhood socioeconomic conditions were taken into account (model 2).
Children's level of physical activity (PA) declines from adolescence [1] and remains low throughout adulthood for many individuals [2], thereby increasing the risk for later cardio-metabolic diseases (CMD) [3].
From postnatal day 7 (P7) to P21, there is an obvious decrease in the protein levels of GluN3A, which remains low into adulthood (Wong et al., 2002).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com