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These compounds generally exhibit low acute toxicity and biological activity.
NB45 exhibited significant antibacterial activity while at the same time retained low acute toxicity.
It also showed acceptable pharmacodynamics profile with very low acute toxicity.
Exposure of the A549 cells revealed the nanotubes to have low acute toxicity, however considerable variation was found depending on the dye employed.
Results showed no acute toxicity (EC50 > 100 mg/L) or very low acute toxicity for most studied oxides.
Moreover, 10M showed low acute toxicity to mice and significant growth inhibition of the hepatoma tumor in vivo.
Finally, HBC showed low acute toxicity to mice and significant growth inhibition of the hepatoma tumor in vivo.
A study designed to determine acute toxicity showed that 1c had low acute toxicity with no significant changes in the weight and no obvious untoward reactions.
Considering the low acute skin toxicity and the complete response in 21 of the 25 subcutaneous melanoma nodules treated, a second irradiation was performed in a different location of the extremity of the same patient.
This finding may be helpful for the design and development of more potent antitumor agents together with low acute toxicity, and suggests that the N-methyl-d-leucine substituent has the potential to be used as antitumor drug lead.
Several of the newly synthesized 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives showed substantial cytostatic and cytotoxic antineoplastic activity invitro, while they have produced relatively low acute toxicities invivo, giving potentially high therapeutic ratios.
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